A. Georgopoulos
University of Vienna
19 Papers
147 Citations
A. Georgopoulos is an academic researcher from University of Vienna. The author has contributed to research in topics: Pharmacokinetics & Fleroxacin. The author has an hindex of 12, co-authored 19 publications.
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Papers
Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans.
Markus Müller,O Haag,T. Burgdorff,A. Georgopoulos,W Weninger,Burkhard Jansen,Gerold Stanek,Hubert Pehamberger,E. Agneter,Hans-Georg Eichler +9 more
TL;DR: It is demonstrated, by means of microdialysis, that the concept of pharmacokinetic/pharmacodynamic surrogate markers for evaluation of antibiotic regimens originally developed for serum pharmacokinetics can be extended to peripheral-tissue pharmacokinetically.
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Impact of plasma protein binding on antimicrobial activity using time–killing curves
Markus Zeitlinger,Robert Sauermann,Friederike Traunmüller,A. Georgopoulos,Markus Müller,Christian Joukhadar +5 more
TL;DR: The data confirm the view that albumin substantially impairs the antimicrobial activity of antibiotics including moxifloxacin, a member of the class of fluoroquinolones.
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A combined in vivo pharmacokinetic–in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans
Simon Delacher,Hartmut Derendorf,Ursula Hollenstein,Martin Brunner,Christian Joukhadar,Sabine Hofmann,A. Georgopoulos,Hans Georg Eichler,Markus Müller +8 more
TL;DR: The experiments show that therapeutic success and failure in antimicrobial therapy may be explained by pharmacokinetic variability at the target site, and the in vivo PK-in vitro PD approach presented in this study may provide valuable guidance for drug and dose selection of antimicrobial agents.
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Relevance of Soft-Tissue Penetration by Levofloxacin for Target Site Bacterial Killing in Patients with Sepsis
Markus Zeitlinger,Pejman Dehghanyar,Bernhard X. Mayer,B. S. Schenk,U. Neckel,Gottfried Heinz,A. Georgopoulos,Markus Müller,Christian Joukhadar +8 more
TL;DR: It is shown that individual differences in the tissue penetration of levofloxacin may markedly affect target site killing of bacteria for which MICs are close to 2 μg/ml, and the extent of bacterial killing could be predicted by calculating individual Cmax/MIC and AUC0-8 muscle/AUC 0-8 plasma free ratios.
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Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues
Martin Brunner,Ursula Hollenstein,Simon Delacher,Dorothea Jäger,Rainer Schmid,Edith Lackner,A. Georgopoulos,Hans Georg Eichler,Markus Müller +8 more
TL;DR: Ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum, and an in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity.
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