A. G. Harris
Aarhus University
6 Papers
107 Citations
A. G. Harris is an academic researcher from Aarhus University. The author has contributed to research in topics: Acromegaly & Octreotide. The author has an hindex of 5, co-authored 6 publications.
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Papers
Continuous subcutaneous pump infusion of somatostatin analogue SMS 201-995 versus subcutaneous injection schedule in acromegalic patients.
S. E. Christensen,Jørgen Weeke,Hans Ørskov,Niels Møller,Allan Flyvbjerg,A. G. Harris,E. Lund,Jens Otto Lunde Jørgensen +7 more
TL;DR: Diurnal serum GH patterns were determined in 10 acromegalic patients, indicating that reduction in insulin antagonistic hormones balanced inhibition of insulin release and in contrast to somatostatin, SMS 201‐995 did not inhibit TSH release.
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Octreotide administration in diabetic rats: Effects on renal hypertrophy and urinary albumin excretion
TL;DR: Chronic administration of SMS has abating effects on diabetic renal hypertrophy and UAE, and thus indicates that SMS may reduce development of diabetic kidney lesions in experimental diabetes.
91
A randomized comparison of intranasal and injectable octreotide administration in patients with acromegaly
Jørgen Weeke,S. E. Christensen,Hans Ørskov,Andreas Kaal,M. Mau Pedersen,P. Illum,A. G. Harris +6 more
TL;DR: Serum octreotide and GH data were subjected to pharmacokinetic analyses, and local nasal effects were evaluated by acoustic rhinometry, showing a highly significant tumescence of the nasal mucosa caused byOctreotide per se and was probably due to vasodilation.
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Effects of antibodies against octreotide in two patients with acromegaly.
TL;DR: Two patients developed specific IgG antibodies against octreotide after 2–3 years’ treatment for acromegaly with this long acting somatostatln analogue and the presence of these antibodies reduced the plasma disappearance rate of total extractableOctreotide by 60 and 80% respectively.
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SMS 201-995 and thyroid function in acromegaly: acute, intermediate and long-term effects.
TL;DR: The only long-term effect of SMS 201-995 was the barely significant clinically irrelevant increase in serum TSH, possibly caused by a slight inhibition of peripheral deiodination of thyroxine.
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