A Elmi
University of London
24 Papers
72 Citations
A Elmi is an academic researcher from University of London. The author has contributed to research in topics: Campylobacter jejuni & Biology. The author has an hindex of 14, co-authored 18 publications.
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Papers
Campylobacter jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial Cells
A Elmi,Eleanor Watson,Pamela Sandu,Ozan Gundogdu,Dominic C. Mills,Neil F. Inglis,Erin D. T. Manson,Lisa Imrie,Mona Bajaj-Elliott,Brendan W. Wren,David Smith,Nick Dorrell +11 more
TL;DR: C. jejuni OMVs possess cytotoxic activity and induce a host immune response from T84 intestinal epithelial cells (IECs), which was not reduced by OMV pretreatment with proteinase K or polymyxin B prior to coincubation with IECs, suggesting OMV induction of IL-8 is independent of CDT.
Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin.
A Elmi,Fauzy Nasher,Heena Jagatia,Ozan Gundogdu,Mona Bajaj-Elliott,Brendan W. Wren,Nick Dorrell +6 more
TL;DR: 11168H OMVs were shown to possess proteolytic activity that was reduced by pretreatment with specific serine protease inhibitors, and further investigation of the cleavage of host cell structural proteins by C. jejuni OMVs should enhance the understanding of the interactions of this important pathogen with intestinal epithelial cells.
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Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for Campylobacter
Umer Zeeshan Ijaz,Lojika Sivaloganathan,Aaron McKenna,Anne Richmond,Carmel Kelly,Mark Linton,Alexandros Ch. Stratakos,Ursula Lavery,A Elmi,Brendan W. Wren,Nick Dorrell,Nicolae Corcionivoschi,Ozan Gundogdu +12 more
TL;DR: A shift from competitive to environmental drivers of microbial community from days 12 to 20 creating a window of opportunity whereby Campylobacter can appear, and a rapidly increasing microbial diversity up to day 12 with variation observed both in terms of genera and abundance.
Campylobacter jejuni Cocultured with Epithelial Cells Reduces Surface Capsular Polysaccharide Expression
Nicolae Corcionivoschi,Marguerite Clyne,A. Lyons,A Elmi,Ozan Gundogdu,Brendan W. Wren,Nick Dorrell,Andrey V. Karlyshev,Billy Bourke +8 more
TL;DR: Campylobacter jejuni alters its surface polysaccharides when cocultured with epithelial cells, suggesting the existence of a cross talk mechanism that modulates CPS expression during infection.
46
Sodium taurocholate stimulates Campylobacter jejuni outer membrane vesicle production via down-regulation of the maintenance of lipid asymmetry pathway
Cadi Davies,Aidan J. Taylor,A Elmi,Jody Winter,Janie Liaw,Anna Grabowska,Ozan Gundogdu,Brendan W. Wren,David J. Kelly,Nick Dorrell +9 more
TL;DR: The data in this study suggests C. jejuni can regulate OMV production in response to host gut signals through changes in expression of the MLA pathway, and highlights the potential importance of diet and lifestyle factors on the varying disease presentations associated with gut pathogen infection.