11 Papers
106 Citations
A. De Pol is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Stem cell & Signal transduction. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of A. De Pol include University of Bologna.
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Papers
Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures
Massimo Riccio,Elisa Resca,Tullia Maraldi,Alessandra Pisciotta,Adriano Ferrari,Giacomo Bruzzesi,A. De Pol +6 more
TL;DR: In this study, DPSCs differentiated in collagen sponge actively secrete human type I collagen micro-fibrils and form calcified matrix containing trabecular-like structures, which may be used in regenerative surgical applications in order to resolve pathologies and traumas characterized by critical size bone defects.
Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.
Jessika Bertacchini,Jessika Bertacchini,Marianna Guida,Benedetta Accordi,Laura Mediani,Am Martelli,Patrizia Barozzi,Emanuel F. Petricoin,Lance A. Liotta,Gloria Milani,Marco Giordan,Mario Luppi,Fabio Forghieri,A. De Pol,Lucio Cocco,Giuseppe Basso,Sandra Marmiroli +16 more
TL;DR: It is demonstrated that dual inhibition of Akt and RTKs displays strong synergistic cytotoxic effects in AML cells and downmodulates Akt signaling to a much greater extent than either drug alone, and should therefore be explored inAML clinical setting.
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Ferutinin promotes proliferation and osteoblastic differentiation in human amniotic fluid and dental pulp stem cells
Manuela Zavatti,Elisa Resca,Laura Bertoni,Tullia Maraldi,Marianna Guida,Gianluca Carnevale,Adriano Ferrari,A. De Pol +7 more
TL;DR: The enhancing capabilities on proliferation and osteoblastic differentiation displayed by the phytoestrogen Ferutinin make this compound an interesting candidate to promote bone formation in vivo.
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MATER protein as substrate of PKCε in human cumulus cells
Tullia Maraldi,Massimo Riccio,Paola Sena,Laura Marzona,A. Nicoli,A. La Marca,Sandra Marmiroli,Jessika Bertacchini,G.B. La Sala,A. De Pol +9 more
TL;DR: Immunoprecipitation and confocal analysis suggest for the first time that MATER protein interacts with this protein kinase in cumulus cells under physiological conditions, which suggests a novel mechanism for the function of MATER in follicular maturation.
Enrichment in c-Kit+ enhances mesodermal and neural differentiation of human chorionic placental cells
Elisa Resca,Elisa Resca,Manuela Zavatti,Laura Bertoni,Tullia Maraldi,S. De Biasi,Alessandra Pisciotta,A. Nicoli,G.B. La Sala,Pascale V. Guillot,Anna L. David,Neil J. Sebire,P De Coppi,A. De Pol +13 more
TL;DR: This work investigated the stem cell characteristics and differentiation potential of a chorionic derived population enriched in c-Kit(+) cells and compared this to the unenriched population and found improved Oct-4 expression and a high differentiation potential into mesodermal lineages and oligodendrocytes.
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