A. Cremers
Maastricht University
45 Papers
91 Citations
A. Cremers is an academic researcher from Maastricht University. The author has contributed to research in topics: Chondrocyte & Medicine. The author has an hindex of 10, co-authored 24 publications. Previous affiliations of A. Cremers include Maastricht University Medical Centre.
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Papers
Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures
Marjolein M. J. Caron,Pieter J. Emans,Marielle M.E. Coolsen,L. Voss,Don A. M. Surtel,A. Cremers,L.W. van Rhijn,Tim J. M. Welting +7 more
TL;DR: For redifferentiation of dedifferentiated HACs, 3D cultures exhibit the most potent chondrogenic potential, whereas a hypertrophic phenotype is best achieved in 2D cultures.
459
Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7.
Marjolein M. J. Caron,Pieter J. Emans,A. Cremers,Don A. M. Surtel,Marielle M.E. Coolsen,L.W. van Rhijn,Tim J. M. Welting +6 more
TL;DR: BMP-2 and BMP-7 display opposing actions on the chondrogenic outcome of differentiating progenitor cells: B MP-2 acts a specific inducer of chondrocyte hypertrophy, while BMP -7 appears to increase or maintain chondrogensic potential and prevent chondROcytehypertrophy.
143
Autologous engineering of cartilage
Pieter J. Emans,Lodewijk W. van Rhijn,Tim J. M. Welting,A. Cremers,Nina Wijnands,Frank Spaapen,J. Willem Voncken,V. Prasad Shastri +7 more
TL;DR: A strategy for de novo engineering of ectopic autologous cartilage (EAC) within the subperiosteal space (in vivo bioreactor) through the mere introduction of a biocompatible gel that might promote hypoxia-mediated chondrogenesis, thereby effectively overcoming the aforementioned limitations.
81
A novel in vivo model to study endochondral bone formation; HIF-1α activation and BMP expression
Pieter J. Emans,Frank Spaapen,Don A. M. Surtel,Keryn Reilly,A. Cremers,Lodewijk W. van Rhijn,Sjoerd K. Bulstra,Jan Willem Voncken,Roel Kuijer +8 more
TL;DR: HIF-1alpha activation and up-regulation of GAPDH support a hypoxia-induced metabolic shift during periosteal chondrogenesis and provides a new experimental system to study and ultimately control tissue regeneration in the adult organism.
61
Novel immortal human cell lines reveal subpopulations in the nucleus pulposus
Guus G. H. van den Akker,Don A. M. Surtel,A. Cremers,Ricardo Rodrigues-Pinto,Stephen M. Richardson,Judith A. Hoyland,Lodewijk W. van Rhijn,Tim J. M. Welting,Jan Willem Voncken +8 more
TL;DR: Evidence is provided that the immortalization strategy that was applied is capable of detecting cell heterogeneity in the NP and suggest that the NP subtypes may correspond to distinct maturation stages and represent distinct NP cell subpopulations.