A C Windsor
VCU Medical Center
15 Papers
222 Citations
A C Windsor is an academic researcher from VCU Medical Center. The author has contributed to research in topics: Lung injury & Sepsis. The author has an hindex of 10, co-authored 15 publications.
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Papers
Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.
A C Windsor,C J Walsh,Patrick G. Mullen,D J Cook,Bernard J. Fisher,Charles R. Blocher,Sandra K. Leeper-Woodford,Harvey J. Sugerman,A A Fowler rd +8 more
TL;DR: It is concluded that anti-TNF alpha suppresses systemic hemodynamic actions of TNF alpha and prevents upregulation of PMN adhesion receptors inhibiting PMN/endothelial cell interaction, which prevents formation of a "microenvironment," protected from circulating oxidant scavengers, into which sepsis-activated PMNs release their toxic products.
Tumor Necrosis Factor-α and Interleukin-6 Selectively Regulate Neutrophil Function in Vitro
TL;DR: This study examined the effect of IL-6 alone and in combination with TNF-alpha on three neutrophil functions--CD18 adhesion receptor expression, phagocytosis, and superoxide anion generation.
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Acute lung injury: what have we learned from animal models?
TL;DR: Using animal model systems led to greater understanding of the pathophysiology of acute lung injury, and with this has come the development of a new generation of agents that may provide a tool with which to combat this disorder.
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Delayed Tumor Necrosis Factor α Blockade Attenuates Pulmonary Dysfunction and Metabolic Acidosis Associated With Experimental Gram-negative Sepsis
A C Windsor,Patrick G. Mullen,C J Walsh,Bernard Fisher,Charles R. Blocher,Gary J. Jesmok,Alpha A. Fowler,Harvey J. Sugerman +7 more
TL;DR: Evidence of PMN-mediated tissue injury in sepsis is supported and mechanisms for potential therapeutic benefit of anti-TNF-alpha treatment in clinical practice are suggested.
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Release of endothelin in relation to tumor necrosis factor-alpha in porcine Pseudomonas aeruginosa-induced septic shock.
J J Han,A C Windsor,D H Drenning,Sandra K. Leeper-Woodford,Patrick G. Mullen,D E Bechard,Harvey J. Sugerman,A A Fowler rd +7 more
TL;DR: TNF-α may cause cardiac dysfunction in sepsis syndrome through increased release of ET through increased releases of immunoreactive endothelin.
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