Invasive aspergillosis of the central nervous system is a rare but well-described disease. There have been only a few reported survivors, and mortality exceeds 95% in the immunosuppressed host. We present a 2-year-old boy with acute lymphatic leukemia and multiple Aspergillus brain abscesses who was successfully treated with liposomal amphotericin B, itraconazole, and surgical excision of the abscesses. Liposomal amphotericin B is a new preparation that safely allows the attainment of significantly higher tissue levels with less toxicity than standard amphotericin B. The treatment of patients with invasive central nervous system aspergillosis is reviewed.

Invasive central nervous system aspergillosis: Cure with liposomal amphotericin b, itraconazole, and radical surgery–case report and review of the literature

Intracranial aspergillus granulomas over a 12-year period were studied retrospectively. Three distinctive types of presentations were seen, namely nine patients had the rhinocerebral form with primary involvement of the air sinuses and secondary involvement of the skull base, cranial nerves and brain, three patients with the apparently purely intracranial form presented like any other space occupying lesion and one patient who had a 'stroke-like' presentation had a parasellar lesion. None of these patients were immunocompromised. The clinical features, and the medical and surgical options are discussed together with outcome.

Intracranial aspergillus granuloma.

Middle and posterior fossa aspergilloma

Orchiectomy was performed in a 37-year-old Hungarian man exhibiting a swelling in his right testicle. Histology revealed a nodule attached to the spermatic cord, consisting of a granulomatous tissue around sections of a nematode. The worm was identified asDirofilaria repens, an uncommon parasite in Hungary. As the patient had been abroad only in Italy where cases of dirofilariosis in dogs and humans are relatively frequent, it is assumed that the infection might have been acquired in that country 5 years earlier. This is the fifth case, published so far in the world, of such a localization in a human. The human cases of dirofilariosis reported in Hungary are reviewed.

/pdf/human-dirofilaria-repens-infection-in-hungary-a-case-in-the-ctffd93dso.pdf

Human Dirofilaria Repens Infection In Hungary: A Case In The Spermatic Cord And A Review Of The Literature

Human dirofilariasis caused by Dirofilaria repens is a parasitic infection, currently considered to be an emerging zoonosis, that has been observed in many areas of the Old World. Dogs are the main 'reservoir' host. In humans, D. repens can cause inflammatory nodules, most commonly in the subcutaneous tissues or in the subconjunctival space. Lung involvement, which is the most common of the non-cutaneous and non-ocular manifestations, is frequently mis-diagnosed as a primary or metastatic lung tumour. Two new subcutaneous cases and one new pulmonary case, all observed in the Egyptian governorate of Assiut, are described here. This represents the first report of human pulmonary dirofilariasis caused by D. repens on the African continent. All the worms collected from the cases, including a living worm from the left lung of the pulmonary case, were identified morphologically, and the identity of the lung parasite was confirmed by PCR.

Three new cases of human infection with Dirofilaria repens, one pulmonary and two subcutaneous, in the Egyptian governorate of Assiut.

Cerebral aspergillotic granuloma. Apropos of a case and a review of the literature

Un cas de dirofilariose souscutanéee en Tunisie

The authors report a case of Scrotal subcutaneous dirofilariasis in man for the first time in Tunisia. The diagnosis was established by pathological examination of a biopsy but the identification of the species was not possible. Surgical exeresis of the node was followed by a complete recovery.

A case of subcutaneous dirofilariasis in Tunisia.

Granulome aspergillaire cérébral : à propos d'un cas et revue de la littérature

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Cerebral aspergillotic granuloma. Apropos of a case and a review of the literature

Un cas de dirofilariose souscutanéee en Tunisie

A case of subcutaneous dirofilariasis in Tunisia.

Granulome aspergillaire cérébral : à propos d'un cas et revue de la littérature