A Bertacca
University of Pisa
9 Papers
108 Citations
A Bertacca is an academic researcher from University of Pisa. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 8, co-authored 9 publications.
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Papers
Serum haptoglobin: a novel marker of adiposity in humans.
Chiara Chiellini,Ferruccio Santini,Alessandro Marsili,Piero Berti,A Bertacca,Caterina Pelosini,Giovanna Scartabelli,E Pardini,J López-Soriano,R Centoni,Annamaria Ciccarone,Luca Benzi,Paolo Vitti,S. Del Prato,Aldo Pinchera,Margherita Maffei +15 more
TL;DR: Serum Hp constitutes a novel marker of adiposity in humans, and the adipose tissue likely contributes to determine its levels, as assessed by dual-energy x-ray absorptiometry.
Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFα
Chiara Chiellini,A Bertacca,Silvia E. Novelli,Cem Z. Görgün,Annamaria Ciccarone,Antonio Giordano,Haiyan Xu,Alexander Soukas,Mario Costa,Daniele Gandini,Roberto Dimitri,Pietro Bottone,P. Cecchetti,Ennia Pardini,Lucia Perego,Renzo Navalesi,Franco Folli,Luca Benzi,Saverio Cinti,Jeffrey M. Friedman,Gökhan S. Hotamisligil,Margherita Maffei +21 more
TL;DR: It is demonstrated that haptoglobin expression in WAT is increased in obesity in rodents and TNFα is an important signal for this regulation.
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Continually high insulin levels impair Akt phosphorylation and glucose transport in human myoblasts.
A Bertacca,Annamaria Ciccarone,P Cecchetti,Barbara Vianello,Incoronata Laurenza,Margherita Maffei,Chiara Chiellini,Stefano Del Prato,Luca Benzi +8 more
TL;DR: Continuous exposure of cultured myoblasts to high insulin levels induces a persistent up-regulation of IR, IRS1, and PI3K activity associated with the demodulation of insulin signaling, which may contribute to the derangement insulin-signaling pathway states of hyperinsulinemia such as obesity and type 2 diabetes.
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Effects of acute or prolonged exposure to human leptin on isolated human islet function.
Roberto Lupi,Piero Marchetti,Margherita Maffei,Del Guerra S,Luca Benzi,Lorella Marselli,A Bertacca,R. Navalesi +7 more
TL;DR: Physiological human leptin concentration is able to importantly affect glucose (but not arginine) stimulated insulin release from human islets only after prolonged exposure, and is probably mediated by changes of potassium channel permeability.
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Plasma leptin levels in newborns from normal and diabetic mothers.
Margherita Maffei,L Volpe,G Di Cianni,A Bertacca,Marco Ferdeghini,S Murru,G Teti,I Casadidio,P Cecchetti,R. Navalesi,Luca Benzi +10 more
TL;DR: The results suggest that degree of adiposity is one of the main regulators of leptin concentration in the human newborn and that babies exposed to an altered, though clinically controlled, metabolic environment, as in IDDM mothers, have increased levels of leptin.
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