A. Barrish
United States Military Academy
13 Papers
176 Citations
A. Barrish is an academic researcher from United States Military Academy. The author has contributed to research in topics: Pharmacokinetics & Atmospheric-pressure chemical ionization. The author has an hindex of 9, co-authored 13 publications.
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Papers
In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia
James C. Barrow,Philippe G. Nantermet,Harold G. Selnick,Kristen L. Glass,Kenneth E. Rittle,Kevin F. Gilbert,Thomas G. Steele,Carl F. Homnick,Roger M. Freidinger,Rick W. Ransom,Paul J. Kling,Duane R. Reiss,Theodore P. Broten,Terry W. Schorn,Raymond S.L. Chang,Stacey O'Malley,Timothy V. Olah,Joan D. Ellis,A. Barrish,Kelem Kassahun,Paula Leppert,Dhanapalan Nagarathnam,Carlos Forray +22 more
TL;DR: While many of the compounds tested displayed poor pharmacokinetics, compound 48 was found to be more potent than terazosin in both a rat model of prostate tone and a dog model of intra-urethral pressure without significantly affecting blood pressure.
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The Use of Stable Isotope Labeling and Liquid Chromatography/Tandem Mass Spectrometry Techniques to Study the Pharmacokinetics and Bioavailability of the Antimigraine Drug, MK‐0462 (Rizatriptan) in Dogs
TL;DR: The assay has been applied to study the pharmacokinetics of MK-0462 after simultaneous oral and intravenous administration of the drug and its stable-isotope-labelled analogue to dogs and afforded an estimate of plasma clearance concomitant with a precise measurement of thedrug's oral bioavailability.
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Non-peptide αvβ3 antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl β-amino acids as aspartic acid replacements
Karen M. Brashear,Hunt Cecilia,Brian T Kucer,Mark E. Duggan,George D. Hartman,Gideon A. Rodan,Sevgi B. Rodan,Chi-Tai Leu,Thomayant Prueksaritanont,Carmen Fernandez-Metzler,A. Barrish,Carl F. Homnick,John H. Hutchinson,Paul J. Coleman +13 more
TL;DR: Modification of the β-alanine 3-substituents alters the potency and physicochemical properties of these receptor antagonists and in some cases provides orally bioavailable α v β 3 inhibitors.
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Determination of the β-adrenergic blocker timolol in plasma by liquid chromatography—atmospheric pressure chemical ionization mass spectrometry
TL;DR: In this paper, a method based on LC-MS-MS has been developed for the determination of timolol in plasma using the (CD 3 ) 3 -labelled species as the internal standard.
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Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.
Karen M. Brashear,Hunt Cecilia,Brian T Kucer,Mark E. Duggan,George D. Hartman,Gideon A. Rodan,Sevgi B. Rodan,Chi-Tai Leu,Thomayant Prueksaritanont,Carmen Fernandez-Metzler,A. Barrish,Carl F. Homnick,Hutchinson John H,Paul J. Coleman +13 more
TL;DR: A series of novel, highly potent alpha(v)beta(3) receptor antagonists with favorable pharmacokinetic profiles has been identified and 2-aryl beta-amino acids function as potent aspartic acid replacements.
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