A. Alhowail
9 Papers
A. Alhowail is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 7 publications.
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Papers
Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis
Amir Mohamed Abdelhamid,M E Youssef,Simona Cavalu,Gomaa Mostafa-Hedeab,Amal Youssef,Sara T. Elazab,Samar H. Ibrahim,Shady Allam,Rehab M Elgharabawy,Eman El-Ahwany,Noha A. Amin,Ahmed Shata,Osama A. Mohammed,Mahmoud Said Ibrahim Abdeldaiem,A. Alhowail,Gaber El-Saber Batiha,Engy A. El-Mahmoudy,Maram Attia,Mona Y. Zaater,Mona Mostafa Osman,Manar A. Nader,Aya Abdul Fattah Taha,Nada Abul Makarem,Sameh Saber +23 more
TL;DR: Investigating the potential coloprotective role of carbocisteine in acetic acid-induced UC by modulating the Nrf2/HO-1 and NFκB interplay in rats provides a potential basis for repurposing a safe and a commonly used mucoregulator for the treatment of UC.
Exploring the focal role of LRRK2 kinase in Parkinson’s disease
Sachin Kumar,Tapan Behl,Aayush Sehgal,Sridevi Chigurupati,Sukhbir Singh,Vasudevan Mani,Maha A Aldubayan,A. Alhowail,Satvinder Kaur,Saurabh Bhatia,Ahmed Al-Harrasi,Vetriselvan Subramaniyan,Shivkanya Fuloria,Neeraj Kumar Fuloria,Mahendran Sekar,Mohamed M. Abdel Daim +15 more
TL;DR: The inhibitor’s capability of L RRK2 kinase to inhibit endolysosomal and neuropathological alterations in human PD indicates that LRRK2 inhibitors could have significant therapeutic usefulness in PD.
7
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
A. Alhowail,Yasser Almogbel,Ahmed A. H. Abdellatif,Maha A Aldubayan,Sridevi Chigurupati,R. A. Nemala +5 more
TL;DR: It is demonstrated that cognitive impairment in CMF and CMF+MET groups could result from increased glutamate and dopamine levels in the brain, leading to brain toxicity and failure of MET to alleviate the toxic effects of CMF.
4
Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons.
TL;DR: The reduction in the activity of mitochondrial complex I and a slight increase in lipid peroxidation levels may explain the cognitive impairment following CMF and MET treatments.
2
Mechanisms underlying cognitive impairment induced by prenatal cannabinoid exposure: a literature review.
A. Alhowail,Maha A Aldubayan +1 more
TL;DR: In this article , a review of the published studies on the mechanisms underlying the effects of prenatal cannabinoid exposure on cognitive impairment is presented, and the findings from the studies reviewed revealed that the cognitive impairment associated with prenatal CB exposure is caused by alterations in the expression and function of endocannabinoid receptor 1 (CB1R), decreased glutamate transmission, reduced neurogenesis, alterations in protein kinase B (PKB/Akt) and extracellular signalregulated kinase 1 and 2 (ERK1/2) activity, and increased mitochondrial function in the hippocampus, cortex, and cerebellum.