A. A. Lashkov
Russian Academy of Sciences
33 Papers
88 Citations
A. A. Lashkov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Uridine phosphorylase & Uridine. The author has an hindex of 6, co-authored 28 publications.
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Papers
The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution.
A. A. Lashkov,N. E. Zhukhlistova,Azat H. Gabdoulkhakov,Alexander A. Shtil,Roman G. Efremov,Christian Betzel,Al'bert M. Mikhailov +6 more
TL;DR: The X-ray crystal structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with its inhibitor 2,2'-anhydrouridine, phosphate and potassium ions has been solved and refined.
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Uridine phosphorylase in biomedical, structural, and functional aspects: A review
TL;DR: The activation of xenobiotics often causes malignant tumor cells to resist chemotherapeutic treatment and high-selectivity anticancer agents based on uridine phosphorylase inhibitors are promising for treating both oncological and infection diseases.
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Expression, purification, crystallization and preliminary X‐ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine
A. A. Lashkov,Azat Gabdulkhakov,I.I. Prokofev,T. A. Seregina,S.E. Sotnichenko,A. V. Lyashenko,Alexander A. Shtil,Alexander Mironov,Christian Betzel,Al'bert M. Mikhailov +9 more
TL;DR: A high-resolution structure of the complex of Vibrio cholerae uridine phosphorylase (VchUPh) with its physiological ligand thymidine is important in order to determine the mechanism of the substrate specificity of the enzyme and for the rational design of pharmacological modulators.
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X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae.
A. A. Lashkov,S.E. Sotnichenko,Igor I. Prokofiev,Azat Gabdulkhakov,Igor I. Agapov,Alexander A. Shtil,Christian Betzel,Alexander Mironov,Al'bert M. Mikhailov +8 more
TL;DR: The X-ray structure of the StUPh-5-FUra complex was analysed at atomic resolution and an in silico model of the complex formed by the drug with UPh from Vibrio cholerae (VchUPh) was generated and should be considered in the design of selective inhibitors of UPhs from various species.
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Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil.
TL;DR: To better understand the mechanism of the enzyme-drug interaction, the complex of Salmonella typhimurium UPh with 5-FU was cocrystallized using the hanging-drop vapour-diffusion method at 294 K and analysis revealed that the crystal belonged to space group C2.
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